3 years ago

Decacationic [70]Fullerene Approach for Efficient Photokilling of Infectious Bacteria and Cancer Cells.

Nayka, Chiang, Hamblin, Huang, Maragani, Wang, Chang, Sharma, Sperandio
Photodynamic inactivation of pathogenic bacteria and cancer cells by novel water-soluble decacationic fullerene monoadducts, C60[>M(C3N6(+)C3)2] and C70[>M(C3N6(+)C3)2], were investigated. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C70[>M(C3N6(+)C3)2] produced more highly reactive HO(•) radical than C60[>M(C3N6(+)C3)2], in addition to singlet oxygen ((1)O2). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C60[>M(C3N6(+)C3)2] and C70[>M(C3N6(+)C3)2], respectively. The hypothesis is that (1)O2 can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO(•) to cause real damage.

Publisher URL: http://doi.org/10.1149/04520.0065ecst

DOI: 10.1149/04520.0065ecst

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