5 years ago

Decacationic [70]Fullerene Approach for Efficient Photokilling of Infectious Bacteria and Cancer Cells.

Nayka, Chiang, Hamblin, Huang, Maragani, Wang, Chang, Sharma, Sperandio
Photodynamic inactivation of pathogenic bacteria and cancer cells by novel water-soluble decacationic fullerene monoadducts, C60[>M(C3N6(+)C3)2] and C70[>M(C3N6(+)C3)2], were investigated. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C70[>M(C3N6(+)C3)2] produced more highly reactive HO(•) radical than C60[>M(C3N6(+)C3)2], in addition to singlet oxygen ((1)O2). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C60[>M(C3N6(+)C3)2] and C70[>M(C3N6(+)C3)2], respectively. The hypothesis is that (1)O2 can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO(•) to cause real damage.

Publisher URL: http://doi.org/10.1149/04520.0065ecst

DOI: 10.1149/04520.0065ecst

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.