3 years ago

RGD peptide modified NaLuF4:Yb,Er nanocrystals for upconversion luminescence targeted tumor cell imaging

Qian Liu, Yemao Wang, Hui Gao, Tianshe Yang, Kenneth Yin Zhang
Upconversion NaLuF4 nanophosphors (UCNPs) with excellent upconversion luminescence (UCL) and good biocompatibility were synthesized by the solvothermal method. The surface of the NaLuF4 UCNPs was modified with the tripeptide arginylglycylaspartic acid (RGD) nanocrystals for targeted tumor cells based on the high and specific affinity to the transmembrane receptor αvβ3 integrin. The morphology, size and UCL properties of the UCNPs were investigated in detail. The methyl thiazolyl tetrazolium (MTT) assay showed low cytotoxicity of the UCNPs to tumor cells and normal cells, indicative of suitability for bioapplication. The RGD modified NaLuF4 nanocrystals have been used for UCL targeted cell imaging in U87MG tumor cells. The results demonstrated that RGD modification allowed the NaLuF4 UCNPs for targeted UCL cell imaging under excitation at 980 nm owing to the high and specific affinity between RGD and the αvβ3 integrin.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejic.201700638

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