European Journal of Inorganic Chemistry
European Journal of Inorganic Chemistry
5 years ago

Carbazole as linker for dinuclear gadolinium based MRI Contrast Agents

Loïck Moriggi, Lothar Helm, Anne-Sophie Chauvin, BibiMaryam Mousavi
Ligands able to complex two gadolinium ions have been synthesized and characterized in view of the ability of the complexes to increase spin relaxation of water protons. All ligands are based on the heptadentate DTTA chelator and carbazole as a rigid linker. Depending on the derivatization on the nitrogen atom of the five-membered ring, the compounds form small aggregates in aqueous solution, self-assemble to form micelles or bind to human serum albumin. In all cases, this leads to a marked increase in 1H relaxivity at nuclear Larmor frequencies between 20 and 60 MHz. Water exchange on the gadolinium ions as measured by 17O NMR relaxation is fast enough not to limit relaxivity. 1H nuclear magnetic relaxation dispersion profiles have been measured and analysed using Solomon-Bloembergen-Morgan theory including Lipari-Szabo treatment to include internal motion or anisotropic rotation.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejic.201700847

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