3 years ago

A novel dual glucagon‐like peptide and glucagon receptor agonist SAR425899: Results of randomized, placebo‐controlled first‐in‐human and first‐in‐patient trials

Maximilian G. Posch, Stefanie Keil, Torsten Haack, Philip J. Larsen, Martin Bossart, Youssef Hijazi, Joachim Tillner, Michael Wagner, Christine Einig, Frank Wagner, Lenore Teichert

Abstract

Aims

To evaluate the safety, pharmacokinetics, and pharmacodynamics of SAR425899, a novel polypeptide active as an agonist at both the glucagon‐like peptide‐1 receptor (GLP‐1 R) and the glucagon receptor, in healthy volunteers and in patients with overweight/obesity and type 2 diabetes.

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