European Journal of Inorganic Chemistry
European Journal of Inorganic Chemistry
4 years ago

Front Cover: Development of Albumin-closo-Dodecaborate Conjugates as Boron Carriers for Neutron-Capture Therapy by Ru(bpy)3-Photocatalyzed Modification of Tyrosine (Eur. J. Inorg. Chem. /2017)

Front Cover: Development of Albumin-closo-Dodecaborate Conjugates as Boron Carriers for Neutron-Capture Therapy by Ru(bpy)3-Photocatalyzed Modification of Tyrosine (Eur. J. Inorg. Chem. /2017)
Shinichi Sato, Hiroyuki Nakamura, Satomu Ishii
The Front Cover shows serum albumin modified with N'-acyl-N,N-dimethylphenylenediamine-functionalized closo-dodecaborate (DB) in the presence of Ru(bpy)3Cl2 photocatalyst under light irradiation. After tyrosine modification, maleimide-functionalized DB molecules are additionally introduced into nucleophilic amino acid residues such as Cys and Lys. The modified serum albumin is delivered to cancer tissue by the enhanced permeability and retention (EPR) effect, and the nuclear reaction of thermal neutrons (yellow particles) with 10B atoms of DB takes place at the cancer tissue, generating α-particles that kill cancer cells. More information can be found in the Communication by H. Nakamura et al. For more on the story behind the cover research, see the Cover Profile.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejic.201701117

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.