Luminescent 1,8-Naphthalimide-Derived ReI Complexes: Syntheses, Spectroscopy, X-ray Structure and Preliminary Bioimaging in Fission Yeast Cells

4 years ago

Luminescent 1,8-Naphthalimide-Derived ReI Complexes: Syntheses, Spectroscopy, X-ray Structure and Preliminary Bioimaging in Fission Yeast Cells

Simon J. A. Pope, Lara M. Groves, Peter N. Horton, Catrin F. Williams, David Lloyd, Anthony J. Hayes, Emily E. Langdon-Jones, Simon J. Coles

A series of picolyl-functionalised, fluorescent 1,8-naphthalimide ligands (L) have been synthesised and coordinated to ReI to form luminescent cationic complexes of the general form fac-[Re(phen)(CO)3(L)]BF4. The complexes were characterised by using a range of spectroscopic and analytical techniques. One example of a complex was also characterised in the solid-state by using single-crystal X-ray diffraction, revealing a distorted octahedral coordination sphere at ReI and Re–C/Re–N bond lengths within the expected ranges. All ligands were shown to be fluorescent, with the 4-amino derivatives showing intramolecular charge transfer in the visible region (511–534 nm). The complexes generally showed a mixture of ligand-centred and/or 3MLCT emission depending upon the nature of the coordinated 1,8-naphthalimide ligand. For selected complexes, confocal fluorescence microscopy was undertaken by using fission yeast cells (Schizosaccharomyces pombe) and showed that the structure of the 1,8-naphthalimide ligand influences the uptake and localisation of the rhenium complex. 1,8-Naphthalimide-derived, picolyl-based ligands have been coordinated to ReI to form luminescent complexes. The complexes were characterised by using an array of spectroscopic methods, and one example provided an X-ray crystal structure. Selected complexes were explored as fluorescence cell imaging agents by using fission yeast cells.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejic.201700549