4 years ago

Synthesis, crystal structure, DNA binding and antitumor studies of β-diketonate complexes of divalent copper, zinc and palladium

Synthesis, crystal structure, DNA binding and antitumor studies of β-diketonate complexes of divalent copper, zinc and palladium
This paper reports a simple approach for the synthesis of three pairs of novel mononuclear β-diketonate complexes of copper(II), zinc(II) and palladium(II) from monobasic O^O donor ligands 3-phenyl-4-fluorobenzolyl-5-isoxazolone (HL1) and 3-phenyl-4-toluyl-5-isxoazolone (HL2). The synthesized compounds are characterized by FT-IR, ESI/FAB mass, 1H NMR, UV–visible and thermogravimetric analyses. The free ligand HL1 and the copper(II) complex, [Cu(L2)2(CH3OH)2] are unambiguously characterized by single crystal X-ray diffraction studies. The free ligand HL1 has adopted orthorhombic crystal system with P2(1) space group and the unit cell parameters are a=8.1552(3), b=10.1169(4), c=17.0819(6) Å, and α=β=γ=90°. The crystal structure of the complex, [Cu(L2)2(CH3OH)2] is monoclinic with P2(1)/c space group and the unit cell parameters are a=10.2571(2), b=16.2640(3), c=20.1717(3)Å, and α=90, β=99.56 and γ=90°. The copper(II) complex has adopted distorted octahedral geometry where the z-axis is occupied by two solvent methanol molecules according to the crystal data. While the EPR spectra of both the Cu(II) complexes display a strong axial signal with g|| 2.2 and g 2.0, which obviously suggests the square planar geometry around the copper(II) ion. The interaction of the complexes with calf thymus DNA (CT-DNA) was investigated using UV–visible and fluorescence spectroscopic techniques. Anticancer activity of the complexes revealed their potential towards inhibiting the growth of human breast cancer cell lines, MDA-MB-231. The palladium complexes of both the ligands are found to be good in exhibiting apoptosis. Moreover, the complexes of fluoro-substituted ligand are better antimicrobial agents when compared with those of methyl substituted ligand.

Publisher URL: www.sciencedirect.com/science

DOI: S0020169317307971

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.