4 years ago

Study of polymorphism in 2, 2′-diselenobis(3-pyridinol)

Study of polymorphism in 2, 2′-diselenobis(3-pyridinol)
2,2′-Diselenobis(3-pyridinol), [2-C5H3N(3-OH)Se]2 (DISPOL) (1) and 3-hydroxypyridine-2-(1H) selone (2) were synthesized and characterized by microanalyses, NMR (1H, 13C{1H}, and 77Se{1H}) spectroscopy. The 1 on recrystallization from various organic and aqueous solutions resulted in different polymorphs which were unambiguously characterized by single crystal X-ray diffraction analyses at room as well as low temperatures. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and differential thermal analysis (DTA) of 1 confirmed the existence of two polymorphs. The bulk 1 and its polymorphs exhibited potent cytotoxicity against A549 human lung carcinoma cells (IC50 values ≈ 10 μM). The compound is thermodynamically stable and is a promising candidate for further pharmacological studies as a cytotoxic agent.

Publisher URL: www.sciencedirect.com/science

DOI: S0022328X17305491

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