4 years ago

New iron cyclopentadienyl complexes bearing different phosphane co-ligands: Structural factors vs. cytotoxicity

New iron cyclopentadienyl complexes bearing different phosphane co-ligands: Structural factors vs. cytotoxicity
A new family of piano stool iron-cyclopentadienyl compounds bearing different phosphane co-ligands has been synthesized. All the compounds, with the general structure [Fe(Cp)(CO)(PR3)(L)]n (PR3 = triphenylphosphane, 4-(diphenylphosphino) benzoic acid or tris(4-fluorophenyl)phosphane; when L = I, n = 0; when L = 4-aminobenzonitrile, n = +1) were fully characterized by the usual analytical and spectroscopic techniques. Interestingly, compound [Fe(Cp)(CO)(PPh3)I] 1 crystalizes in the orthorhombic space group P212121 and its crystal packing only contains one enantiomer, while compound [Fe(η5-Cp)(CO)(P(Ph-p-F)3)I] 3 crystalizes in the centrosymmetric space group Pbca presenting an important disorder in the structure, probably due to the presence of the two enatiomers in the crystal packing. All the compounds presented adequate stability in aqueous solution and they were tested against cervical HeLa human cancer cells. The cationic complexes bearing triphenylphosphane ( 4 ) or tris(4-fluorophenyl)phosphane ( 6 ) were found to be highly cytotoxic, causing cell death by apoptosis. The results point out that the electronic features of the new compounds might be related to their cytotoxic activity.

Publisher URL: www.sciencedirect.com/science

DOI: S0022328X17305806

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