5 years ago

Structural elucidation and bioassays of newly synthesized pentavalent antimony complexes

Structural elucidation and bioassays of newly synthesized pentavalent antimony complexes
Antimony (V) organometallics (15) have been synthesized with general formula [SbR′3(O2CR)2], where R' = phenyl, p-tolyl and O2CR are substituted cinnamates. These complexes have been characterized by FT-IR analysis, multinuclear (1H, 13C) NMR spectroscopy and single crystal X-ray diffraction analysis. The crystal structures of [Sb(phenyl)3(4-ClC6H4C2H2O2C)2] (1) and [Sb(p-tol)3(4-OCH3C6H4C2H2O2C)2].CHCl3 (5) displayed distorted geometry between trigonal bipyramidal and square pyramidal with monomeric structure at a five coordinated Sb center. Starting reagents and complexes were evaluated for anticancer, antileishmanial, antibacterial and alpha amylase inhibition potentials. It was observed that complexes 3, 4 and 5 showed significant (p < 0.05) antileishmanial and anticancer activities against Leishmania tropica KWH23 promastigotes and HepG2 cell lines respectively. Antibacterial activity of compound 3 was also significant against E. coli (MIC: 5.55 μg/mL), K. pneumoniae (MIC: 16.66 μg/mL), S. aureus (MIC: 5.55 μg/mL) and P. aeruginosa (MIC: 50 μg/mL). Hence, these new antimony complexes can act as good drug candidates.

Publisher URL: www.sciencedirect.com/science

DOI: S0022328X17305132

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