4 years ago

Synthesis, characterization and anticancer evaluation of phosphinogold(I) thiocarbohydrate complexes

Synthesis, characterization and anticancer evaluation of phosphinogold(I) thiocarbohydrate complexes
Several novel thiocarbohydrate phosphinogold(I) complexes were prepared via the reaction of n-gluconamidoalkyl thiol (L1L7) {where L1–L4 = n-gluconamidoalkyl thiol (n =1–4), L5–L7 =acetylated n-gluconamidoalkyl thiol (n =1–3)} with the gold precursors [AuCl(PPh3)], [Au2Cl2(dppe)], [Au2Cl2(dppp)] and [Au2Cl2(dppb)], leading to the new gold(I) complexes [Au(L1)(PPh3)] (14), [Au(L5)(PPh3)] (57), [Au2(L1)2(dppe)] (811), [Au2(L5)2(dppx)] (1214), [(Au2(L6)2)(dppx)] (1517), [Au2(L7)2(dppx)] (1820), {where dppe=1,2-bis(diphenylphosphino)ethane (x=e), dppp=1,3-bis(diphenylphosphino)propane (x=p) and dppb=1,4-bis-(diphenylphosphino)butane (x=b)}. These gold complexes were characterized by a combination of NMR and infrared spectroscopy, microanalysis and mass spectrometry. Complexes 8, 12, 1416 (IC50 values between 0.003 and 1.8μM) are all active against MCF7, HCT116 and PC3 cells. Complex 8 recorded the highest IC50 value of 0.003μM against PC3. Complex 14 was found to be selective towards both MCF7 and PC3 cells with a TS value of 142.1, while compounds 15 and 16 were highly selective toward PC3 cells with TS values of 970.0 and 937.5, respectively.

Publisher URL: www.sciencedirect.com/science

DOI: S0277538717305879

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