3 years ago

Synthesis, X-ray structure, DFT calculations and anticancer activity of a selenourea coordinated gold(I)-carbene complex

Synthesis, X-ray structure, DFT calculations and anticancer activity of a selenourea coordinated gold(I)-carbene complex
A gold(I)-carbene complex, [Au(IPr)(Seu)]PF6 (1), where Seu=Selenourea and IPr=1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene, was prepared using [Au(IPr)Cl] and characterized by elemental analysis, IR, and NMR (1H, 13C, 77Se) methods. The crystal structure of 1 was determined by single-crystal X-ray diffraction analysis, which shows that the complex (1) adopts a linear geometry about gold(I). The structures of the [Au(IPr)(Seu)]PF6 monomer as a model of 1 and that of the dimer, {[Au(IPr)(Seu)]PF6}2 were optimized at the B3LYP-D3 level of theory. The DFT results give support to the experimentally determined monomeric structure. The in vitro cytotoxic activity of [Au(IPr)Cl] and complex 1 was investigated against three human cancer cell lines; A549(lung carcinoma), HCT15(colon cancer) and MCF7(breast cancer). The IC50 values showed that the selenourea-containing complex (1) was less potent than cisplatin in inhibiting the growth of cancer cells. The stability of complex 1 in phosphate buffered aqueous solution and its interaction with amino acids; glutathione and l-cysteine were studied using square wave stripping voltammetry.

Publisher URL: www.sciencedirect.com/science

DOI: S0277538717305223

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.