3 years ago

TLR7‐let7 signaling contributes to ethanol‐induced hepatic inflammatory response in mice and in alcoholic hepatitis

Pau Sancho‐Bru, Veronica L Massey, Joaquin Cabezas, Juan Caballeria, Fulton Crews, Liya Qin, Ramon Bataller

Abstract

Background

Toll like receptor 7 (TLR7) is an endosomal TLR that is activated by ssRNA, including endogenous microRNAs (e.g. let‐7b). Increased hepatic expression of TLRs, microRNAs, and inflammatory mediators are linked to ethanol exposure and to alcoholic liver disease (ALD). ALD invovles chronic hepatic inflammation that can progress to alcoholic hepatitis (AH), a particularly severe form of ALD. This study aimed to investigate TLR7 expression in patients with different liver disease phenotypes and in mouse liver following alcohol exposure.

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