Accounts of Chemical Research
Accounts of Chemical Research
5 years ago

Jumping Hurdles: Peptides Able To Overcome Biological Barriers

Jumping Hurdles: Peptides Able To Overcome Biological Barriers
Ernest Giralt, Meritxell Teixidó, Macarena Sánchez-Navarro
The cell membrane, the gastrointestinal tract, and the blood–brain barrier (BBB) are good examples of biological barriers that define and protect cells and organs. They impose different levels of restriction, but they also share common features. For instance, they all display a high lipophilic character. For this reason, hydrophilic compounds, like peptides, proteins, or nucleic acids have long been considered as unable to bypass them. However, the discovery of cell-penetrating peptides (CPPs) opened a vast field of research. Nowadays, CPPs, homing peptides, and blood–brain barrier peptide shuttles (BBB-shuttles) are good examples of peptides able to target and to cross various biological barriers.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00204

DOI: 10.1021/acs.accounts.7b00204

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