3 years ago

Jumping Hurdles: Peptides Able To Overcome Biological Barriers

Jumping Hurdles: Peptides Able To Overcome Biological Barriers
Ernest Giralt, Meritxell Teixidó, Macarena Sánchez-Navarro
The cell membrane, the gastrointestinal tract, and the blood–brain barrier (BBB) are good examples of biological barriers that define and protect cells and organs. They impose different levels of restriction, but they also share common features. For instance, they all display a high lipophilic character. For this reason, hydrophilic compounds, like peptides, proteins, or nucleic acids have long been considered as unable to bypass them. However, the discovery of cell-penetrating peptides (CPPs) opened a vast field of research. Nowadays, CPPs, homing peptides, and blood–brain barrier peptide shuttles (BBB-shuttles) are good examples of peptides able to target and to cross various biological barriers.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00204

DOI: 10.1021/acs.accounts.7b00204

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.