Synthesis, crystal structure, DNA/BSA interaction and in vitro antitumor activity of N-heterocycle Cu(II) and Co(II) complexes
![Synthesis, crystal structure, DNA/BSA interaction and in vitro antitumor activity of N-heterocycle Cu(II) and Co(II) complexes](/image/eyJ1cmkiOiJ0YW5kZm9ubGluZS5jb20vbmExMDEvaG9tZS9saXRlcmF0dW0vcHVibGlzaGVyL3RhbmRmL2pvdXJuYWxzL2NvbnRlbnQvZ2NvbzIwLzAvZ2NvbzIwLmFoZWFkLW9mLXByaW50LzAwOTU4OTcyLjIwMTcuMTM3MjU3My8yMDE3MDkxNC9pbWFnZXMvbWVkaXVtL2djb29fYV8xMzcyNTczX3VmMDAwMV9vYy5qcGciLCJmb3JtYXQiOiJ3ZWJwIiwicXVhbGl0eSI6MTAwLCJub0NhY2hlIjp0cnVlfQ==.webp)
Investigation of N-heterocycle transition metal complexes has led to the discovery of metal-based antitumor agents. Herein, two binuclear complexes, [Cu(p-4-bmb)(Ac)2]2 (1) and [Co(p-4-bmp)Cl2]2 (2), were prepared and characterized. The interactions of 1 and 2 with calf thymus (CT)-DNA and bovine serum albumin (BSA) were detected by absorbance and emission spectroscopy. The complexes bind to CT-DNA via an intercalative mode and show moderate affinity to BSA. Both complexes exhibited remarkable DNA cleavage activity. The MTT assay demonstrated that 1 exhibited higher cytotoxicity against three human alimentary system carcinoma cell lines compared to 2. Further, a cellular uptake assay demonstrated that 1 can accumulate in the nucleus and mitochondria of SMMC7721 cells to induce DNA damage and mitochondrial dysfunction. Fluorescence staining and flow cytometry analyses revealed that 1 can induce cell death by apoptosis. These findings should promote the development of benzimidazole-based transition metal complexes as novel chemotherapy agents with fewer side effects than conventional antitumor drugs.
Publisher URL: http://www.tandfonline.com/doi/full/10.1080/00958972.2017.1372573
DOI: 10.1080/00958972.2017.1372573
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