Bacterial sensitivity and SOD behavior of N-pyrone glucosamine Schiff base Fe(III) complex: conjoint experimental-DFT evaluation
Iron and sugar are essential components of life processes. In the evident interest toward Fe(III) compounds to explore the ability of sugars toward metallotherapy, a systematic hyphenated DFT-experimental study of a novel sugar Schiff base Fe(III) complex of general composition [Fe(L)(OH)], where L = N-dehydroacetic acid-glucosamine (dha-glsH2), is presented. Based on various experimental spectrometric and spectroscopic characterization techniques in combination with theoretical data, a suitable distorted tetragonal structure is suggested for the complex. In addition to the formulation of the synthesized complex, superoxide dismutase (SOD) mimetic, and antimicrobial actions have also been the active goal of the work. A promising superoxide dismutazing potential with IC50 = 69 μM was found. But on the other hand antibacterial action of the complex has shown less sensitivity to be called as efficient bactericidal agent.
Publisher URL: http://www.tandfonline.com/doi/full/10.1080/00958972.2017.1374381
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