3 years ago

New Ni(II) complexes involving symmetrical bidentate N,O-donor Schiff base ligands: synthesis at ambient temperature, crystal structures, electrochemical study, antioxidant and cytotoxic activities

New Ni(II) complexes involving symmetrical bidentate N,O-donor Schiff base ligands: synthesis at ambient temperature, crystal structures, electrochemical study, antioxidant and cytotoxic activities
Ali Khaleghian, Maciej Kubicki, Mehdi Salehi, Zeinab Abbasi

A new series of Ni(II) complexes, [Ni(L1)2] (1), [Ni(L2)2] (2), [Ni(L3)2] (3), and [Ni(L4)2] (4), were synthesized at ambient temperature. The bidentate Schiff base ligands HL1−4 have been obtained by the condensation reaction of 2-hydroxybenzaldehyde, 5-bromo-2-hydroxybenzaldehyde, 3-methoxy-2-hydroxy-benzaldehyde, and 4-methoxy-2-hydroxy-benzaldehyde, respectively, with 2-methoxyethylamine. The newly synthesized complexes were characterized by elemental analyses, FT-IR and UV–vis spectroscopy. The crystal structures of mononuclear Ni(II) complexes 2 and 3 were determined by the single-crystal X-ray diffraction technique. Electrochemical properties of the complexes were investigated in acetonitrile. The antioxidant properties of the Schiff base ligands and complexes were evaluated by two in vitro tests, DPPH radical scavenging and reducing power. The compounds were screened for their in vitro anticancer potential using gastric cancer cell lines by MTT assay. All ligands and complexes showed considerable cytotoxic activity against cancer cell lines (IC50 = 0.2516–5.468 μg·mL−1). The most promising result was achieved for complex 1 with the best IC50 value of 0.2516 μg·mL−1. It was found that the proliferation rate of MKN-45 cells decreased after treatment with the complexes in a dose-dependent way.

Publisher URL: http://www.tandfonline.com/doi/full/10.1080/00958972.2017.1373189

DOI: 10.1080/00958972.2017.1373189

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.