3 years ago

Synthesis and characterization of iminophosphineplatinum(II) complexes of the type (κ 2 - P,N -2-Ph 2 PC 6 H 4 C(H)=NC 6 H 4 X)PtCl 2 (X = OMe, F)

Stephen A. Westcott, Pier Jr. Morin, Meghan E. Adams, Christopher M. Vogels, Darcie L. Stack, Patrick-Denis St-Coeur, Bryanna J. Kenny, Jason D. Masuda


A series of iminophosphineplatinum(II) complexes have been prepared from pro-ligands derived from aniline derivatives containing electron-donating methoxy groups or electron-withdrawing fluorides and [PtCl2(η 2 − coe)]2 (coe = cis-cyclooctene). All new pro-ligands and metal complexes have been fully characterized, including an X-ray diffraction study for compound 11 (derived from para-methoxyaniline). Additionally, the molecular structure of a di-iminophosphineplatinum dication 11a has been determined. The platinum compounds showed no appreciable cytotoxic properties against two glioma cell lines using the MTT method.

Publisher URL: https://link.springer.com/article/10.1007/s11243-017-0176-2

DOI: 10.1007/s11243-017-0176-2

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