4 years ago

Oxidation in vitro of chromium(III) dietary supplements mer -[Cr(pic) 3 ] and trans (S,S)-[Cr(Cys) 2 ] − by hydrogen peroxide

Ewa Kita, Anna Katafias, Emilia Nieczyporowska, Anna Bajek, Łukasz Kaźmierski


Biological tests performed using 3T3 fibroblasts indicated low cytotoxicities for the complexes mer-[Cr(pic)3] and trans(S,S)-[Cr(Cys)2], where pic = picolinate anion and Cys = cysteine. Oxidation of these complexes by hydrogen peroxide was studied in NaOH and NaHCO3 media. Electronic (UV–Vis) and EPR spectroscopies were used to monitor the reaction course. Hydrogen peroxide oxidizes chromium(III) to both [CrV(O2)4]3− and CrVIO4 2− anions in alkaline media and practically completely to CrO4 2− anion in bicarbonate solution. The reactions follow consecutive biphasic or simple first-order kinetics. The first-order decay of [CrV(O2)4]3− anion at pH ≈ 8 was followed by EPR spectroscopy. Based on the obtained kinetic and spectroscopic data, mechanisms for the redox transformations of these chromium(III) complexes are proposed.

Publisher URL: https://link.springer.com/article/10.1007/s11243-017-0168-2

DOI: 10.1007/s11243-017-0168-2

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