Organic Letters
Organic Letters
3 years ago

Coupling Reaction of Cu-Based Carbene and Nitroso Radical: A Tandem Reaction To Construct Isoxazolines

Coupling Reaction of Cu-Based Carbene and Nitroso Radical: A Tandem Reaction To Construct Isoxazolines
Wenhao Long, Shangwen Fang, Xiaobing Wan, Yanwei Zhao, Hongmei Sun, Rongxiang Chen
In this letter, an unprecedented cross-coupling reaction between copper carbene and nitroso radical has been developed. This radical-carbene coupling reaction (RCC reaction) offers a novel approach for the preparation of various isoxazolines, which features the construction of C–C, C–O, and C═N bonds in a one-pot process. The synthetic utility of our method is further enhanced by its mild reaction conditions, wide substrate scope, and simple procedures.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02885

DOI: 10.1021/acs.orglett.7b02885

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