3 years ago

PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters [Biochemistry]

PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters [Biochemistry]
Jennifer M. Gerlach, Dirk Birkel, Maria Gallant, Peter Gallant, Elmar Wolf, Apoorva Baluapuri, Michael Furrer

The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc’s binding to its transcriptional targets. Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the PAF1 complex is typically associated with active genes, this interaction with Leo1 contributes to Myc targeting to open promoters.

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