3 years ago

Enzymatic Generation of Highly Anticoagulant Bovine Intestinal Heparin

Enzymatic Generation of Highly Anticoagulant Bovine Intestinal Heparin
Yanlei Yu, Lei Lin, Payel Datta, Navdeep Grover, Fuming Zhang, Jonathan S. Dordick, Daisuke Mori, Li Fu, Murat Yalcin, Makoto Hirakane, Kevin Li, Robert J. Linhardt, Shaker A. Mousa, Jing Zhao
Unlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1, -3, and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin.

Publisher URL: http://dx.doi.org/10.1021/acs.jmedchem.7b01269

DOI: 10.1021/acs.jmedchem.7b01269

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.