3 years ago

An orally administered oral pathobiont and commensal have comparable and innocuous systemic effects in germ‐free mice

Mai Yokoji, Miki Yamada, Kazuhisa Yamazaki, Takako Nakajima, Keisuke Sato


Background and Objectives

We recently proposed a novel mechanism linking periodontitis and systemic diseases, in which orally administered Porphyromonas gingivalis affects gut microbiota composition and subsequently leads to systemic inflammation. However, the mechanism by which P. gingivalis generates systemic effects from the gut is unknown.

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