Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Frontispiece: From Peptides to Peptidomimetics: A Strategy Based on the Structural Features of Cyclopropane

Frontispiece: From Peptides to Peptidomimetics: A Strategy Based on the Structural Features of Cyclopropane
Kouhei Matsui, Akira Mizuno, Satoshi Shuto
The use of cyclopropane in peptidomimetic chemistry, focusing on the importance of 3D structural diversity for effective lead identification, is the subject of the Minireview by Shuto et al. on page 14394 ff. Cyclopropane, the smallest carbon ring, is an irreplaceable tool for medicinal chemists to regulate the conformation of molecules in a three-dimensionally diverse manner because of its characteristic structural features. Accordingly, the library of conformationally restricted peptidomimetics based on cyclopropane produces suitable leads mimicking key conformations of the parent peptides.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201785862

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