4 years ago

Biocatalytic asymmetric Michael addition reaction of L-arginine to fumarate for the green synthesis of N-(([(4S)-4-amino-4-carboxy-butyl]amino)iminomethyl)-L-aspartic acid lithium salt (L-argininosuccinic acid lithium salt)

Biocatalytic asymmetric Michael addition reaction of L-arginine to fumarate for the green synthesis of N-(([(4S)-4-amino-4-carboxy-butyl]amino)iminomethyl)-L-aspartic acid lithium salt (L-argininosuccinic acid lithium salt)
B. Schoenenberger, R. Meier, A. Wszolek, M. Obkircher, H. Brundiek, R. Wohlgemuth
The biocatalytic asymmetric Michael addition of L-arginine to fumarate using argininosuccinate lyase (ASL) has enabled the synthesis of the key metabolite L-argininosuccinic acid lithium salt 1 for the first time, with excellent yield and purity.

Publisher URL: http://feeds.rsc.org/~r/rss/ra/~3/foDHEXiQbjM/C7RA10236D

DOI: 2017/RA/C7RA10236D

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