4 years ago

One-pot synthesis of benzimidazole using DMF as a multitasking reagent in presence CuFe2O4

One-pot synthesis of benzimidazole using DMF as a multitasking reagent in presence CuFe2O4
One pot synthesis of benzimidazole from o-nitroaniline was achieved by using CuFe2O4 as a catalyst. It comprises the reduction of o-nitroaniline followed by cyclization, without using an external H2 source. The thermal decomposition of DMF in situ generates CO, which undergo water gas shift reaction (WGSR) in presence of CuFe2O4 to produce hydrogen. It reduces −NO2 (nitroaniline) to −NH2 (o-phenylenediamine, OPD). The further cyclisation of OPD to benzimidazole was done by using DMF as a C1 source, in presence of magnetically separable CuFe2O4 as catalyst. This is the first example of its kind being reported here. The catalyst was prepared by a simple hydrothermal method, with the environmentally benign starting material. CuFe2O4 is cheap and reusable having very low toxicity. This is an economical synthetic protocol for benzimidazole from o-nitroaniline with 100% conversion in 12h with 97.5% selectivity. A variety of o-nitroaniline substrates were studied for this protocol with excellent conversion and selectivity.

Publisher URL: www.sciencedirect.com/science

DOI: S0920586117307010

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