Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis
5 years ago

Formation of N-Unprotected Isoindolinones From Benzylamines via Cobalt-Catalyzed Traceless Directing Group-Assisted C(sp2)−H Carbonylation

Formation of N-Unprotected Isoindolinones From Benzylamines via Cobalt-Catalyzed Traceless Directing Group-Assisted C(sp2)−H Carbonylation
Fei Ling, Yaping Lv, Weihui Zhong, Chongren Ai
The front cover picture, provided by Weihui Zhong and co-workers, illustrates the first example of cobalt-catalyzed C(sp2)−H carbonylation of benzylamines using a traceless directing group, which was successfully applied to the synthesis of N-unprotected isoindolinones through direct C−H/N−H bonds activation. This protocol tolerates a variety of functional groups and provides a facile and efficient method for the formal synthesis of (+)-garenoxacin. Details of this work can be found in the communication on pages XXXX–XXXX (F. Ling, C. Ai, Y. Lv, W. Zhong, Adv. Synth. Catal. 2017, 359, XXXX–XXXX; DOI: 10.1002/adsc.201700780)

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201701283

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