3 years ago

<i>Vibrio vulnificus</i> induces mTOR activation and inflammatory responses in macrophages

X. Frank Yang, Jian-Chun Guo, Jie Zhang, Meng-Meng Zheng, Ting Zhang, Xiao-Ping Zhong, Hui Gao, Dan-Li Xie, Yong-Liang Lou, Yi Zheng

by Dan-Li Xie, Meng-Meng Zheng, Yi Zheng, Hui Gao, Jie Zhang, Ting Zhang, Jian-Chun Guo, X. Frank Yang, Xiao-Ping Zhong, Yong-Liang Lou

Vibrio vulnificus (V. vulnificus), a Gram-negative marine bacterium, can cause life-threatening primary septicemia, especially in patients with liver diseases. How V. vulnificus affects the liver and how it acts on macrophages are not well understood. In this report, we demonstrated that V. vulnificus infection causes a strong inflammatory response, marked expansion of liver-resident macrophages, and liver damage in mice. We demonstrated further that V. vulnificus activates mTOR in macrophages and inhibition of mTOR differentially regulates V. vulnificus induced inflammatory responses, suggesting the possibility of targeting mTOR as a strategy to modulate V. vulnificus induced inflammatory responses.

Publisher URL: http://journals.plos.org/plosone/article

DOI: 10.1371/journal.pone.0181454

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