3 years ago

Feto‐ and utero‐placental vascular adaptations to chronic maternal hypoxia in the mouse

Lisa X. Yu, Lindsay S. Cahill, Monique Y. Rennie, Christopher K. Macgowan, Johnathan Hoggarth, Mike Seed, John C. Kingdom, John G. Sled, Anum Rahman


Key points

  • Chronic fetal hypoxia is one of the most common complications of pregnancy and is known to cause fetal growth restriction.
  • The structural adaptations of the placental vasculature responsible for growth restriction with chronic hypoxia are not well elucidated.
  • Using a mouse model of chronic maternal hypoxia in combination with micro‐computed tomography and scanning electron microscopy, we found several placental adaptations that were beneficial to fetal growth including capillary expansion, thinning of the interhaemal membrane and increased radial artery diameters, resulting in a large drop in total utero‐placental vascular resistance.
  • One of the mechanisms used to achieve the rapid increase in capillaries was intussusceptive angiogenesis, a strategy used in human placental development to form terminal gas‐exchanging villi.
  • These results contribute to our understanding of the structural mechanisms of the placental vasculature responsible for fetal growth restriction and provide a baseline for understanding adaptive physiological responses of the placenta to chronic hypoxia.

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.