Journal of Biophotonics
Journal of Biophotonics
3 years ago

Reconnectable fiberscopes for chronic in vivo deep-brain imaging

M.A. Roshchina, I.V. Fedotov, A.B. Fedotov, D.A. Sidorov-Biryukov, M.S. Pochechuev, K.V. Anokhin, D.V. Meshchankin, A.M. Zheltikov, O.I. Ivashkina
Reconnectable bundles consisting of thousands of optical fibers are shown to enable high-quality image transmission, offering a platform for the creation of implantable fiberscopes for minimally invasive in vivo brain imaging. Experiments on various lines of transgenic mice verify the performance of this fiberscope as a powerful tool for chronic in vivo neuroimaging using genetically encoded calcium indicators, neuronal activity markers, as well as axon growth regulators and brain-specific protein drivers in deep regions of live brain.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jbio.201700106

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