Journal of the American Chemical Society
Journal of the American Chemical Society
5 years ago

Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity

Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity
Rebecca A. Vipond, Peter Scott, Daniel E. Mitchell, Matthew I. Gibson, Guy Clarkson, David J. Fox
Antifreeze proteins are produced by extremophile species to control ice formation and growth, and they have potential applications in many fields. There are few examples of synthetic materials which can reproduce their potent ice recrystallization inhibition property. We report that self-assembled enantiomerically pure, amphipathic metallohelicies inhibited ice growth at just 20 μM. Structure–property relationships and calculations support the hypothesis that amphipathicity is the key motif for activity. This opens up a new field of metallo-organic antifreeze protein mimetics and provides insight into the origins of ice-growth inhibition.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b05822

DOI: 10.1021/jacs.7b05822

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