3 years ago

Experimental Design in Clinical ‘Omics Biomarker Discovery

Experimental Design in Clinical ‘Omics Biomarker Discovery
Jenny Forshed
This tutorial highlights some issues in the experimental design of clinical ‘omics biomarker discovery, how to avoid bias and get as true quantities as possible from biochemical analyses, and how to select samples to improve the chance of answering the clinical question at issue. This includes the importance of defining clinical aim and end point, knowing the variability in the results, randomization of samples, sample size, statistical power, and how to avoid confounding factors by including clinical data in the sample selection, that is, how to avoid unpleasant surprises at the point of statistical analysis. The aim of this Tutorial is to help translational clinical and preclinical biomarker candidate research and to improve the validity and potential of future biomarker candidate findings.

Publisher URL: http://dx.doi.org/10.1021/acs.jproteome.7b00418

DOI: 10.1021/acs.jproteome.7b00418

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