3 years ago

Controlled Recrystallization of Tubular Vinpocetine Crystals with Increased Aqueous Dissolution Rate and In Vivo Bioavailability

Controlled Recrystallization of Tubular Vinpocetine Crystals with Increased Aqueous Dissolution Rate and In Vivo Bioavailability
Shichao Du, Yaping Wang, Junbo Gong, Panpan Sun, Zhenping Wei, Mingyang Chen, Shijie Xu, Sohrab Rohani, Ergang Liu
The graphic shows the obtained vinpocetine hollow tubular crystal (right SEM image) by antisolvent crystallization using the bulk material (left SEM image). Left curve graph illustrates tubular crystal has increased dissolution rate than the raw VIN in water with 0.5% SDS and right plasma concentration−time plots show that tubular VIN achieves a faster higher Cmax and an improved AUC0-t.

Publisher URL: http://dx.doi.org/10.1021/acs.cgd.7b00806

DOI: 10.1021/acs.cgd.7b00806

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