Accounts of Chemical Research
Accounts of Chemical Research
5 years ago

Phage Selection of Cyclic Peptides for Application in Research and Drug Development

Phage Selection of Cyclic Peptides for Application in Research and Drug Development
Christian Heinis, Xu-Dong Kong, Kaycie Deyle
Cyclic peptides can bind to protein targets with high affinities and selectivities, which makes them an attractive modality for the development of research reagents and therapeutics. Additional properties, including low inherent toxicity, efficient chemical synthesis, and facile modification with labels or immobilization reagents, increase their attractiveness. Cyclic peptide ligands against a wide range of protein targets have been isolated from natural sources such as bacteria, fungi, plants, and animals. Many of them are currently used as research tools, and several have found application as therapeutics, such as the peptide hormones oxytocin and vasopressin and the antibiotics vancomycin and daptomycin, proving the utility of cyclic peptides in research and medicine.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00184

DOI: 10.1021/acs.accounts.7b00184

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