3 years ago

Anti-inflammatory/infection PLA nanoparticles labeled with technetium 99m for in vivo imaging

Nathalia Martins Alexandre Pinheiro, Thereza Christina Barja-Fidalgo, Cristal Cerqueira-Coutinho, Sara Rhaissa Rezende dos Reis, Suyene Rocha Pinto, Fiammetta Nigro, Heitor Affonso Paula Neto, Ralph Santos-Oliveira, Sofia Nascimento dos Santos

Abstract

Despite advancements in treatment of infectious diseases, opportunistic pathogens continue to pose a worldwide threat. Identifying a source of infection/inflammation is often challenging which highlights the need of improved diagnostic agents. Using a model of local S. aureus infection, here we evaluated the potential of betamethasone or dexamethasone loaded in poly (lactic acid) nanoparticles and radiolabeled with 99mTc to detect an infection/inflammation site in vivo. A betamethasone and dexamethasone nanoparticles (NPs) with 200 and 220 nm in size, respectively, were created with a 98% 99mTc radiolabeling efficiency. When injected in infected mice, betamethasone NPs presented a higher accumulation in the infected hind paw in comparison with dexamethasone NPs. Our results suggest that this nanosystem may be a valid nanoradiopharmaceutical for the detection of inflammation/infection foci in vivo.

Graphical abstract

Nanoradiopharmaceutical for inflammation

Publisher URL: https://link.springer.com/article/10.1007/s11051-017-4037-x

DOI: 10.1007/s11051-017-4037-x

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