3 years ago

Augmented Zika and dengue neutralizing antibodies are associated with Guillain-Barré syndrome.

Guangzhao Li, Eva Harris, Nelly Pacheco, Gary L Simon, Monica Rengifo-Pardo, Alejandro R Mendoza, Magelda Montoya Cruz, Jeff M Bethony, Rebecca M Lynch, Grace Mantus, Jin Peng, Aileen Y Chang, Liliana Encinales, Alexandra Porras
The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared to uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared to non-GBS ZIKV infected controls. These data suggest that high neutralizing antibodies titers to DENV and to ZIKV are associated with GBS during ZIKV infection.

Publisher URL: http://doi.org/10.1093/infdis/jiy466

DOI: 10.1093/infdis/jiy466

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