Organic Letters
Organic Letters
5 years ago

Palladium/Copper-Catalyzed Oxidative Coupling of Arylboronic Acids with Isocyanides: Selective Routes to Amides and Diaryl Ketones

Palladium/Copper-Catalyzed Oxidative Coupling of Arylboronic Acids with Isocyanides: Selective Routes to Amides and Diaryl Ketones
Lingtong Fang, Cong Li, Xiaoyan Wang, Xinyue Peng, Ziyue Chen, Aiwen Lei, Meng Gao, Zhen Li, Dong Liu, Fangling Lu
An efficient and alternative oxidative cross-coupling strategy starting from arylboronic acids and isocyanides for the selective synthesis of amides and diaryl ketones with palladium/copper catalysis is developed. Various substituted benzamides and benzophenones could be obtained in good yields. The reaction represents an efficient and alternative strategy for the synthesis of carbonyl compounds.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01548

DOI: 10.1021/acs.orglett.7b01548

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