3 years ago

Prior exercise training improves cold tolerance independent of indices associated with non‐shivering thermogenesis

Carly M. Knuth, Paula M. Miotto, Anders Gudiksen, David C. Wright, Willem T. Peppler, Logan K. Townsend

Abstract

Key points

  • Mammals defend against cold‐induced reductions in body temperature through both shivering and non‐shivering thermogenesis. The activation of non‐shivering thermogenesis is primarily driven by uncoupling protein‐1 in brown adipose tissue and to a lesser degree by the browning of white adipose tissue.
  • Endurance exercise has also been shown to increase markers of white adipose tissue browning.
  • This study aimed to determine whether prior exercise training would alter the response to a cold challenge and if this would be associated with differences in indices of non‐shivering thermogenesis.
  • It is shown that exercise training protects against cold‐induced weight loss by increasing food intake. Exercise‐trained mice were better able to maintain their core temperature, independent of differences in markers of non‐shivering thermogenesis.

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