ChemBioChem
ChemBioChem
5 years ago

Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: A Comparative Study

Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: A Comparative Study
Hui Zhao, Yanhong Jiang, Dongyuan Wang, Jingxu Li, Zigang Li, Yuan Tian
The cover feature shows a comparative study of the effect of different stapling architectures on the physiochemical properties and cell permeability of stapled peptides. The choice of stapling architecture exhibits the decisive impact of the properties of the crosslinkers on cell permeability, rather than peptides′ helical contents, in a model amphipathic sequence targeting the interaction between the estrogen receptor and its coactivator. This finding should shed further light on the chemical optimization of stapled α-helical peptides or macrocyclic cell-penetrating peptides for enhanced penetration. More information can be found in the communication by Z. Li et al..

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cbic.201700551

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