3 years ago

Redirecting Killer T Cells through Incorporation of Azido Sugars for Tethering Ligands

Redirecting Killer T Cells through Incorporation of Azido Sugars for Tethering Ligands
Demin Zhou, Weiling Wang, Qing Xia, Chuanling Zhang, Xinshan Ye, Lihe Zhang, Ziwei Zhang, Sulong Xiao, Zhiying Zhao
The cover picture shows a chemical approach to generating tumor-specific cytotoxic T cells by using Ac4ManNAz as a small-molecule engager. T cells were first cultured in Ac4ManNAz and then incubated with Alexa Fluor 488 dibenzocyclooctynol (DIBO) to achieve the tumor-specific targeting. These tumor-specific cytotoxic T cells amplified and secreted cytokines after interaction with tumor cells. This method poses no risk of insertional mutagenesis, thereby making it feasible as a safe approach for the production of tumor-specific cytotoxic T cells in cancer immunotherapy. More importantly, the displayed azido moiety and the tethered ligands remain stable only for a few days, thus allowing the control of cytotoxicity and cytokine release. This chemical approach provides a facile platform for the rational design of tumor-specific cytotoxic T cells for targeted immunotherapy. More information can be found in the communication by Q. Xia, D. Zhou et al..

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cbic.201700549

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