3 years ago

Generation of six multiple sclerosis patient-derived induced pluripotent stem cell lines.

B Kuebler, Y Muñoz, L Miquel-Serra, M Martí, A Veiga, X Montalban, S Malhotra, C Costa, B Aran, A Duarri, M Comabella, A Raya
Multiple sclerosis (MS) is considered a chronic autoimmune disease of the central nervous system that leads to gliosis, demyelination, axonal damage and neuronal death. The MS disease aetiology is unknown, though a polymorphism of the TNFRSF1A gene, rs1800693, is known to confer an increased risk for MS. Using retroviral delivery of reprogramming transgenes, we generated six MS patient-specific iPSC lines with two distinct genotypes, CC or TT, of the polymorphism rs1800693. iPSC lines had normal karyotype, expressed pluripotency genes and differentiated into the three germ layers. These lines offer a good tool to study MS pathomechanisms and for drug testing.

Publisher URL: http://doi.org/10.1016/j.scr.2017.06.001

DOI: 10.1016/j.scr.2017.06.001

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