3 years ago

Effects of hyperoxia on myocardial injury following cardioversion – a randomized clinical trial

Oxygen has long been assumed beneficial for all ill and injured patients. However, hyperoxia may be harmful and aggravate myocardial injury such as that caused by myocardial infarction. We aimed to investigate if hyperoxia increases myocardial injury following direct current cardioversion compared with room air. Methods Patients undergoing elective biphasic cardioversion for atrial fibrillation or atrial flutter were randomized to receive room air or oxygen (10–15L/ minute) during the procedure. The primary endpoint was the difference in high-sensitive Troponin I (hs-cTnI) and -T (hs-cTnT) measured 2hours before and 4hours after cardioversion. Secondary endpoints were differences in Copeptin and NT-pro-BNP. Results A total of 65 patients were randomized to high flow oxygen (male: 71%, mean age 66.9years) and 59 patients to room air (male: 80%, mean age 65.5years). There was no difference in hs-cTnI between patients treated with oxygen compared to patients treated with room air (P =.09) and no significant difference for hs-cTnT, ratio 1.08 (95% CI: 0.99–1.18) (P=.09). Median hs-cTnI difference before and after cardioversion was 0.1 (interquartile range (IQR): −0.5 - 0.5) ng/L for the high flow oxygen group and −0.3 (IQR: -1.1 – 0.4) ng/L for the room air group. There was no difference in Copeptin between patients treated with oxygen compared to room air (ratio 1.06 (95% CI: 0.89–1.27) (P =.51) or NT-pro-BNP (difference−6.0ng/L (95% CI: -78.5 – 66.6) P =.87). Conclusion Direct current cardioversion of atrial fibrillation/flutter with and without high-flow oxygen supplement was not associated with myocardial injury evaluated by high sensitive myocardial biomarkers. Trial registration number: NCT02317029

Publisher URL: www.sciencedirect.com/science

DOI: S0002870317303186

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