Reaction screening and optimization of continuous-flow atropine synthesis by preparative electrospray mass spectrometry

5 years ago

Reaction screening and optimization of continuous-flow atropine synthesis by preparative electrospray mass spectrometry

R. Graham Cooks, David H. Thompson, Zinia Jaman, Andy Koswara, Michael Wleklinski, Caitlin E. Falcone

Reaction mixtures are screened by droplet ES synthesis; optimum reagents and conditions as determined using MS analysis are then transferred to a microfluidic system. This rapid screening/optimization approach is applied to the synthesis of atropine.

Publisher URL: http://feeds.rsc.org/~r/rss/AN/~3/P3CSSlZoVmE/C7AN00622E

DOI: 2017/AN/C7AN00622E

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