3 years ago

Severe Cytomegalovirus Enterocolitis Developing following Daratumumab Exposure in Three Patients with Multiple Myeloma

Haggai Bar‐Yoseph, Noam Benyamini, Ilana Oren, Edmond Sabo, Noa Lavi, Doaa Okasha

Abstract

Survival of multiple myeloma (MM) patients has improved with introduction of novel anti‐myeloma agents. Myeloma has transformed into a chronic condition, accompanied with multiple relapses requiring salvage therapies, which results in cumulative immunosuppression. The impact of novel therapies on the immune system differs from that of traditional chemotherapy, and their application leads to emergence of infections not previously associated with myeloma, cytomegalovirus (CMV) infection being one of them(1).

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