3 years ago

Hepatic zonation now on hormones!

Sungjin Ko, Satdarshan P Monga


The liver plays important roles in maintaining systemic metabolic homeostasis, but our understanding of how the liver coordinates such a wide range of functions is still evolving. A recent study led by Dr. Gromada advanced the knowledge of the regulators for liver zonation with the discovery of a novel role for glucagon as a liver metabolic zonation regulator utilizing Glucagon (gcg) KO mice combined with RNA sequencing and in situ hybridization (ISH) (1). The established mechanism of metabolic liver zonation is determined by the architecture of the liver, which is composed of millions of hepatic lobules the basic functional units within each of the lobes of the liver.

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