CD14—New Tricks of an Old Acquaintance
Zanoni et al. (2017) show that the LPS receptor CD14 promotes internalization of oxidized phospholipids, a hallmark of dying cells, triggering hyperactivation of dendritic cells and macrophages. Their findings reveal CD14 as a regulator of responses to infection and damage, relaying context-dependent signals that determine inflammatory cell fate decisions.
Publisher URL: http://www.cell.com/immunity/fulltext/S1074-7613(17)30434-X
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