4 years ago

iNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury

iNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury
Paul Kubes, Woo-Yong Lee, Pei Xiong Liew


After traumatic injury, some cells function as detectors to sense injury and to modulate the local immune response toward a restitution phase by affecting the local cytokine milieu. Using intravital microscopy, we observed that patrolling invariant natural killer T (iNKT) cells were initially excluded from a site of hepatic injury but subsequently were strategically arrested first via self-antigens and then by cytokines, circumscribing the injured site at exactly the location where monocytes co-localized and hepatocytes proliferated. Activation of iNKT cells by self-antigens resulted in the production of interleukin-4 (IL-4) but not interferon-γ (IFN-γ). This promoted increased hepatocyte proliferation, monocyte transition (from Ly6Chi to Ly6Clo), and improved healing where IL-4 from iNKT cells was critical for these processes. Disruption of any of these mechanisms led to delayed wound healing. We have shown that self-antigen-driven iNKT cells function as sensors and orchestrators of the transformation from inflammation to tissue restitution for essential timely wound repair.

Publisher URL: http://www.cell.com/immunity/fulltext/S1074-7613(17)30427-2

DOI: 10.1016/j.immuni.2017.09.016

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