4 years ago

Socioeconomic Status and Childhood Cancer Incidence: A Population-Based Multilevel Analysis.

David M Vock, Theresa L Osypuk, Rebecca D Kehm, Logan G Spector, Jenny N Poynter
The etiology of childhood cancers remains largely unknown, especially regarding environmental and behavioral risk factors. Unpacking the association between socioeconomic status (SES) and incidence may offer insight into such etiology. We tested associations between SES and childhood cancer incidence in a population-based case-cohort study (source cohort: Minnesota birth registry, 1989-2014). Cases, 0-14 years, were linked from the Minnesota Cancer Surveillance System to birth records through probabilistic record linkage. Controls were 4:1 frequency matched on birth year (2,947 cases, 11,907 controls). We tested associations of individual-level (maternal education) and neighborhood-level (census tract composite index) SES using logistic mixed models. In unadjusted models, maternal education was positively associated with incidence of acute lymphoblastic leukemia (odds ratio (OR) = 1.10; 95% confidence interval (CI): 1.02, 1.19), central nervous system tumors (OR = 1.12; 95% CI: 1.04, 1.21), and neuroblastoma (OR = 1.15; 95% CI: 1.02, 1.30). Adjustment for established risk factors, including race/ethnicity, maternal age, and birthweight, substantially attenuated these positive associations. Similar patterns were observed for neighborhood-level SES. Conversely, higher maternal education was inversely associated with hepatoblastoma incidence (adjusted OR = 0.70; 95% CI: 0.51, 0.98). Overall, beyond the social patterning of established demographic and pregnancy-related exposures, SES is not strongly associated with childhood cancer incidence.

Publisher URL: http://doi.org/10.1093/aje/kwx322

DOI: 10.1093/aje/kwx322

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.