3 years ago

Invited Commentary: Sex-Race differences in diabetes and cardiovascular disease: Achieving the promise of sex and race subgroup analyses in epidemiologic research.

Alain G Bertoni, Nathalie Moise
Diabetes confers a higher risk of cardiovascular disease in women than men. The reasons for these sex differences, such as poorer cardiovascular risk factor profiles, have received considerable attention. However, a recent report on sex-diabetes interactions on cardiovascular disease identified that few if any prior studies have confirmed these sex-differences in blacks, despite known diabetes-related disparities. In the current issue of the Journal, George et al. (2017) find marginally significant multiplicative sex by diabetes interactions in blacks but not whites after adjustments for traditional and behavioral risk factors, competing risk and change in diabetes status over time. This study is notable for its attempt to fill an important literature gap and elegantly address multiple statistical considerations in assessing sex-diabetes interactions by race strata. The findings also highlight several important considerations in conducting race and sex subgroup analyses.

Publisher URL: http://doi.org/10.1093/aje/kwx327

DOI: 10.1093/aje/kwx327

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