3 years ago

Bioinformatics for immunologists

Daniel M. Altmann

Summary

Immunology was once a specialty prone to cause dismay or even scepticism among outsiders for its struggles to visualize poorly understood, complex interactions through descriptive models integrating cell types, their factors and functions. This was the age of ‘too many soft ideas propped up by too little hard data’. Twenty‐first century immunologists have the advantage of being able to marry this rich conceptual legacy to a contemporary toolkit offering such depth of hard data across different ‘omics’ platforms, that they are faced by the opposite dilemma: ‘too much hard data to comprehend or synthesize into a meaningful narrative’. Approaches including next‐generation sequencing of host and pathogen genomes and transcriptomes, metagenomics of the microbiota, creative strategies for receptor repertoire sequencing, and then for proteomics and metabolomics, encompass all that is needed to tell the entire story, if only we are creative enough, not only to evaluate the message from any given omics platform, but to derive the tools that enable us to integrate the answers from diverse omics platforms in a meaningful way. To achieve this goal, there is an urgent need to ensure we train the next generation of bioinformatically literate researchers.

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.